• CLL associated HLH was first documented

  2019-05-20

  

  CLL associated HLH was first documented in the form of a case series report which included six patients treated for CLL who subsequently developed the phagocytic syndrome months to years later.[7] As these cases occurred prior to publication of the 1991 HLH diagnostic guidelines, the authors postula

• gnrh agonists br Discussion CML was the

  2019-05-20

  

  Discussion CML was the first malignancy to be linked to a clear genetic abnormality, the Philadelphia chromosome. This chromosomal abnormality is so named because of the city in which it was first discovered and described in 1960 by Peter Nowell and David Hungerford [1]. The fusion protein result

• A structured inherited arrhythmia or heart disease clinic pr

  2019-05-20

  

  A structured inherited arrhythmia (or heart disease) clinic provides the platform for optimized multidisciplinary evaluation and management of patients and families with suspected inherited heart disease. The collective efforts of the core staff and access to a variety of experts in related discipli

• mdm2 inhibitor Visto el franquismo como el gran eje de

  2019-05-20

  

  Visto el franquismo como el gran eje de la discordia, el punto de in flexión se produjo en 1949 con motivo de la presentación en la onu de una propuesta conjunta de cuatro países de América Latina: Brasil, Bolivia, Colombia y Perú. La propuesta de resolución del cuatripartito latinoamericano (proyec

• Uric acid level was high

  2019-05-20

  

  Uric akt inhibitor level was high at presentation but not at a level where nephropathy is usually expected. Yet, uric acid increased with creatinine until administration of rasburicase. Whether this increase was enough to cause or contribute to the ARF is uncertain. Comparably, Larsen and Loghman-A

• Data on chloroquine resistance from Pakistan is scarce

  2019-05-18

  

  Data on chloroquine resistance from Pakistan is scarce, even in the most recent global analysis. Nevertheless, in 2013, the emergence of the F1076L mutant of the gene—the comt inhibitor responsible for chloroquine resistance—in in Pakistan highlights the imminent threat of resistant . In 2015, th

• br A KCNJ mutation corresponding to an S L

  2019-05-18

  

  A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6

• After overdrive pacing excitation that is one

  2019-05-18

  

  After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The exci

• Assim a decis o de avan ar

  2019-05-18

  

  Assim, g-quadruplex decisão de avançar sobre Lima deve ser entendida antes como uma “fuga para frente” do que como desdobramento de um crescimento orgânico. Mas em seu momento, havia um genuíno receio em relação ao poder insurgente, já que a repercussão das ações senderistas na capital era amplifica

• In patients with systolic heart failure and a wide

  2019-05-17

  

  In patients with systolic heart failure and a wide QRS complex, cardiac resynchronisation therapy (CRT) using left ventricular (LV) pacing has been shown to enhance survival, reduce heart failure hospitalisation and enhance exercise capacity in patients with all Go 6976 of heart failure. The patien

• retinoid x receptor br Discussion The natural history of

  2019-05-17

  

  Discussion The natural history of PMF is characterized by the possibility of blastic transformation in approximately 20% of all the cases [9]. Several factors might predict leukemic transformation, including percentage of circulating blasts, low platelets count and the presence of an unfavorable

• Perhaps counter intuitively the most strategic tobacco contr

  2019-05-17

  

  Perhaps counter-intuitively, the most strategic tobacco control policies to reduce adolescent smoking and secondhand smoke exposure in LMICs may not be those targeting adolescents. Targeted campaigns can be expensive, and are unlikely to be as effective as the more affordable tobacco control policie

• National coverage trends were accelerated because

  2019-05-17

  

  National coverage trends were accelerated because of the contribution of trends in the two poorest quintiles. In middle-income countries, for example, the estimated increase in national trends was around 25% faster as a result of the contribution of poor populations. Increases in coverage in rural a

• Cardiologic examination and detailed analysis of lead rest E

  2019-05-17

  

  Cardiologic examination and detailed analysis of 12-lead rest ECG were performed by an experienced cardiologist (E.C.) and reevaluated by another independent cardiologist (S.R.). According to Groh et al., severe ECG abnormality included at least one of the following: rhythm other than sinus; PR inte

• The OptiVol Fluid Index OVFI

  2019-05-17

  

  The OptiVol Fluid Index (OVFI), which is derived from changes in intrathoracic impedance, can effectively assess HF by analyzing the changes in the intrathoracic impedance detected by the original OptiVol algorithm. Small et al. previously determined that a frequent and extended threshold crossing c

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