• The effects of the endocrine

  2019-09-18

  

  The effects of the endocrine active agents on hepatic ERα were varied. Both nonylphenol and genistein caused an increase in hepatic ERα in female rats, whereas EE2 did not. It is doubtful that the small changes in hepatic ERα induced by genistein and nonylphenol in female rats are sufficient to alte

• We have previously shown that sustained pCPT treatment favor

  2019-09-18

  

  We have previously shown that sustained 8-pCPT treatment favored Ca2+-dependent arrhythmogenic activity in rat ventricular cardiomyocytes [8]. Fig. 2 shows line-scan Ca2+ images of myocyte incubated without (Fig. 2A left) and with 8-pCPT (Fig. 2A right) subjected to a train of electrical stimulation

• In vitro studies suggest that cPLA does not

  2019-09-18

  

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr

• The present study was the first to examine

  2019-09-17

  

  The present study was the first to examine how COMT genotype and estradiol are associated with moles to grams calculator functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would remain a

• Early studies from the mollusk Aplysia reported

  2019-09-17

  

  Early studies from the mollusk, Aplysia, reported the presence of a unique class of glucokinase receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis elegans (Putrenko et al.,

• In patients with CTEPH ET levels

  2019-09-17

  

  In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary HhAntag by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed in air embolus

• The role of Epac in the regulation of intracellular Ca

  2019-09-17

  

  The role of Epac in the regulation of intracellular Ca homeostasis and contractility is still matter of debate. In rat adult cardiomyocytes, acute Epac stimulation decreased the amplitude of Ca transients [6], [9], [10] with either no changes [6] or increments [9] in cell shortening, suggesting an e

• br Introduction Vitis vinifera L is one of

  2019-09-17

  

  Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat

• Possibly there are similarities among euphorb plant species

  2019-09-17

  

  Possibly there are similarities among euphorb plant species but extraction of the pde inhibitors present in the microsomal fraction is needed for testing their preferences for substrates. Although R. communis, E. lathyris and E. lagascae belong to the same family, the DGAT activity of their microsom

• In Hevea brasiliensis both the soluble

  2019-09-17

  

  In Hevea brasiliensis, both the soluble PPase and the membrane-bound V-PPase are present in the latex; the soluble PPase is in the C-serum (cytosol) of the latex [6] and the V-PPase is on the tonoplast of the lutoid, a special vacuole in the laticifers of rubber trees [7]. The V-PPase on the lutoid

• Autophagy alterations are frequently reported

  2019-09-17

  

  Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein hiv protease inhibitors in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were des

• br Pre clinical combination studies using CSF CSF R inhibito

  2019-09-17

  

  Pre-clinical combination studies using CSF-1/CSF-1R inhibitors In preclinical models, the CSF-1R pathway can be blocked by using either small molecule kinase inhibitors (GW2580 [30], PLX3397 [31], Ki20227 [32], BLZ945 [33] and CYC11645 [34]), antibody-mediated inhibition of CSF-1 using 5A1 [35] o

• All these results indicate that cleaving

  2019-09-16

  

  All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner TCS 2002 pathway and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and our p

• A different example of substrate dependent activation is

  2019-09-16

  

  A different example of substrate-dependent activation is seen in CSN5, a JAMM-type DUB found in the eight subunit COP9 signalosome (CSN) [34]. The CSN deconjugates NEDD8 (neural precursor cell expressed developmentally downregulated 8) from Cullin Ring ubiquitin E3 ligases (CRLs). Through this activ

• In addition to demonstrating the importance

  2019-09-16

  

  In addition to demonstrating the importance of DNMTs, we show that TGFβ1 differentially regulated DNMTs, and that TGFβ1 is both necessary and sufficient to induce lineage conversion of hepatocytes into MLCs with phenotypes and multipotency resembling MSCs. Upon withdrawal of TGFβ1 on day 28, we obse

15868 records 980/1058 page Previous Next First page 上5页 976977978979980 下5页 Last page