• Stability of DBS over the

  2021-09-09

  

  Stability of DBS over the 60-day time points was encouraging, with a maximum of 0.1 log10 IU/mL degradation from the day 1 value (Supplementary Fig. 1 and Supplementary Table 3). Discussion This study evaluated the sensitivity and specificity of the Aptima HCV Dx assay for HCV RNA detection fro

• Prolonged sGC oxidative inhibition occurs in many

  2021-09-08

  

  Prolonged sGC oxidative inhibition occurs in many diseases [46,[86], [87], [88]]. Keeping sGC membrane-bound and functional under conditions of high oxidative stress requires a mechanism for restoring oxidized sGC (Fe3+) heme iron to its reduced (Fe2+) state. Without this redox regulation, the sGC e

• GSTP is a class Glutathione S transferase

  2021-09-08

  

  GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting ICI 118,551 hydrochloride against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in prost

• Others demonstrated that Paneth cells maintain stem cell fun

  2021-09-08

  

  Others demonstrated that Paneth cells maintain stem cell function and crypt homeostasis by providing metabolic lactate to sustain the enhanced mitochondrial oxidative phosphorylation in the Lgr5+ ISCs (Rodriguez-Colman et al., 2017), which substantially agrees with our findings in this study. Furthe

• br Experimental br Results and discussions br Conclusions

  2021-09-08

  

  Experimental Results and discussions Conclusions In this work, a novel label-free ECL biosensing method was developed to detect TDG activity using signal amplification strategy of HCR which was triggered by DNA functionalized AuNPs. The label-free ECL biosensing platform has been constructe

• Recently Bristol Myers Squibb and

  2021-09-08

  

  Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic Oxaliplatin derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole GPR40 agonist

• At the heart of ferroptosis is a process of

  2021-09-08

  

  At the heart of ferroptosis is a process of lethal lipid peroxidation, which is the oxidative addition of molecular oxygen (O2) to lipids, such as polyunsaturated fatty acyl tails in phospholipids. The first descriptions of such enzymatic reactions were in 1955 by Peterson and colleagues [50] and Ro

• It is important to note that histamine H

  2021-09-07

  

  It is important to note that histamine H1 and H2 receptors are coupled to different G proteins and that their crossinterference induced by histamine H1 and H2 receptor inverse agonists depends on the cointernalization mechanism. To date, histamine H1 and H2 receptor inverse agonist have shown to int

• It is not established if ONOO also induces tyrosine nitratio

  2021-09-07

  

  It is not established if ONOO− also induces tyrosine nitration of ANT and affects VDAC1 and ANT interaction, as well as the interaction of VDAC1 with HK II, all of which are events that may lead to altered mitochondrial and cellular function. Thus, in this study we examined tyrosine nitration of bot

• Materials and methods Standard curve for http

  2021-09-07

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• To this end we evaluated novel D analogs for

  2021-09-07

  

  To this end, we evaluated novel D22 analogs for selectivity to inhibit substrate transport in OCT2, OCT3, and PMAT heterologous cell Carmustine mg systems, and in mouse hippocampal and striatal preparations. Chosen analogs were based upon availability of essential chemical precursors (e.g. 6-substi

• Work in the Ruiz i Altaba lab was funded

  2021-09-07

  

  Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from

• br Pannexins which form channels connecting cells with

  2021-09-06

  

  Pannexins, which form channels connecting bosentan with the extracellular environment, have also been studied in the setting of NASH. When open these channels participate in inflammatory processes. A decrease in lobular inflammation and oxidative stress was observed in mice with pannexin deletion.

• The advent of the genomic era has allowed greater

  2021-09-06

  

  The advent of the genomic era has allowed greater detailed investigation of enzymatic properties and has shown that specific enzyme activity is linked to the substrate utilization profiles of the isoenzymes [30], [31]. Not surprisingly, the functional four β-galactosidases from A. niger F0215 shared

• A majority of aptamer based biosensors termed

  2021-09-06

  

  A majority of aptamer-based biosensors (termed aptasensors) is based on structure-switching process of aptamer probes upon target binding [[12], [13], [14], [15]]. And canonical structure-switching aptamer probes are strand-displacement aptamer probes, aptamer beacons and split aptamers [[16], [17],

15881 records 606/1059 page Previous Next First page 上5页 606607608609610 下5页 Last page