• br Conclusion Growth survival and invasion of most PCs have

  2023-08-26

  

  Conclusion Growth, survival, and invasion of most PCs have been shown to be androgen-dependent at the onset of castration therapy [31]. Thus, castration therapy has been central to systemic therapy and remains the standard approach to PC treatment. Even after progression to a castration-resistant

• In this paper we describe

  2023-08-26

  

  In this paper, we describe the formation of a structure-based pharmacophore which lead to the discovery of several hydrophobic, yet non-lipid inhibitors of ATX. These compounds docked within the same volume occupied by the initial non-lipid inhibitors of ATX used to build the pharmacophore. Violatio

• br Ataxia telangiectasia and Rad related as a

  2023-08-26

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• Thiamet G receptor ATM is generally regarded to be the

  2023-08-26

  

  ATM is generally regarded to be the principal mediator of the G1 Thiamet G receptor checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type

• br Asthma The chronic airway inflammatory

  2023-08-26

  

  Asthma The chronic airway inflammatory disease MCB-613 is associated with enhanced levels of exhaled NO generated by iNOS in the airway epithelium [12]. In asthmatic patients local and systemic changes in iNOS, peroxynitrite, arginase, ADMA and arginine levels have been observed and are associat

• We further conducted stratified analyses

  2023-08-26

  

  We further conducted stratified analyses to observe changes in enzyme levels across the periods by subgroups. Fig. 1 shows the changes in GPx levels by subgroups of age, sex, and smoking status. In all participants, GPx levels decreased when air pollution levels declined but increased after the Olym

• br Introduction It is well known that when

  2023-08-26

  

  Introduction It is well known that when epithelial cells are deprived of anchorage, they undergo detachment-induced apoptosis, also known as anoikis. Cancer cells, by contrast, are able to suppress anoikis and survive under anchorage -independent conditions in the circulating system, which is tho

• br Acknowledgements br Introduction Microbial enzymes have g

  2023-08-26

  

  Acknowledgements Introduction Microbial enzymes have gained interest for their widespread uses in industries and medicine owing to their stability, catalytic activity, and ease of production and optimization than plant and animal enzymes (Singh et al., 2016). Microbial aminopeptidases (amino-a

• The evidence points toward a role for LO

  2023-08-26

  

  The evidence points toward a role for 12/15-LO activity in WAT in modulating chronic local inflammation and subsequent systemic metabolic decline in the obese state. However, little is known as to the role of 12- and 15-LOs in BAT. Indeed, in addition to WAT, platelet- and leukocyte-type 12-LO are e

• br Impact of global AHR

  2023-08-26

  

  Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s

• br Materials and methods br Results br Discussion br Conclus

  2023-08-25

  

  Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic GW788388

• AdipoRon The biological characteristics of cancer invasion a

  2023-08-25

  

  The biological characteristics of cancer invasion and metastasis are mainly attributed to the poor prognosis in cancer. It has been reported that overexpression of Ack1 promoted the migratory and invasive properties of breast cancer AdipoRon by sustaining expression of epidermal growth factor. In c

• Introduction Lysophosphatidic acid LPA is a key

  2023-08-25

  

  Introduction Lysophosphatidic chloroquine phosphate (LPA) is a key, serum-borne phospholipid, regulating a number of cellular processes such as proliferation, migration and differentiation through its interaction with G-protein coupled receptors. LPA receptor signaling has been implicated in sever

• DRiPs also contribute to formation of protein aggregates

  2023-08-25

  

  DRiPs also contribute to formation of protein Thioguanine that result from dysregulation of proteostasis, during which the proteolytic machinery is unable to process and degrade defective proteins (Tyedmers et al., 2010). Aggregation of poly-ubiquitinated proteins has been observed in different cel

• Production of reactive oxygen species ROS

  2023-08-25

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the Ciprofibrate receptor [26]. Several studies have indicated that the 12/15-

15891 records 294/1060 page Previous Next First page 上5页 291292293294295 下5页 Last page