• Another research group assessed pairs of

  2023-09-20

  

  Another research group assessed 8503 pairs of middle-aged (toll like receptors the twin exposed to surgery had lower scores on cognitive tests in 49% of the pairs. Twins aged 70 and older who underwent hip and knee arthroplasty scored higher on cognitive tests, even higher than those who had not und

• Interestingly hypoxia and an enhanced Warburg effect

  2023-09-20

  

  Interestingly, hypoxia and an enhanced Warburg effect ultimately lead to increased lactate production. The accumulation of lactate results in an acidic tumor microenvironment, which induces local inflammation. Lactate also promotes the polarization of macrophages that express immunosuppressive argin

• HT modulates cortical and hippocampal pyramidal cell functio

  2023-09-20

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal carboxypeptidase as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et

• The discovery of acetylsalicylic acid aspirin in paved the w

  2023-09-20

  

  The discovery of acetylsalicylic Obeticholic Acid (aspirin) in 1897 paved the way for the development of classical NSAIDs as first-line therapeutics for anti-inflammatory, anti-pyretic and analgesic therapy. Large efforts have been made in the following decades to improve the efficacy and in partic

• br Acknowledgements We thank Dr Stefan Schulte Merker

  2023-09-20

  

  Acknowledgements We thank Dr. Stefan Schulte-Merker and his group members at the Hubrecht Institute (Utrecht, the Netherlands) for their invaluable support of the zebrafish studies. Our work is supported by grants from the Dutch Cancer Society (KWF) and the Netherlands Organisation for Scientific

• Fig summarizes the oxidative metabolism of arachidonic acid

  2023-09-20

  

  Fig. 1 summarizes the oxidative metabolism of arachidonic 77 9 receptor by lipoxygenases cyclooxygenases and cytochrome P450. Lipoxygenases in humans are expressed in a tissue-specific fashion: 5-LOX is mainly expressed in leukocytes, 12-LOX in platelets, and 15-LOX-1 in reticulocytes, eosinophils,

• Calcineurin has been established to be

  2023-09-20

  

  Calcineurin has been established to be a ubiquitous Ca2+-activated serine phosphatase in the nervous system (Pyrzynska et al., 2001). It has been reported that the activation of calcineurin protects aromatase from autophagy-mediated protein degradation, implying that calcineurin-dependent dephosphor

• Hydrogen sulfide H S a

  2023-09-20

  

  Hydrogen sulfide (H2S) [33], a colorless and water-soluble gas with the smell of rotten eggs, is now recognized as an important gasotransmitter, after the extensive study of nitric oxide (NO) and carbon monoxide (CO). H2S is produced endogenously via enzymatic reactions of cysteine, homocysteine and

• Epalrestat Bamboo shoots with their high nutritive http www

  2023-09-20

  

  Bamboo shoots, with their high nutritive and therapeutic value, are now used for food fortification (Nirmala & Bisht, 2017). Several value-added products such as nuggets, crackers, chutney, snacks, cookies, cakes, chappaties, and buns have been prepared from bamboo shoots (Table 3). Dietary fiber fr

• br Role of AR in models

  2023-09-19

  

  Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig

• br Conclusions In sum enhanced incentive motivation

  2023-09-19

  

  Conclusions In sum, enhanced incentive motivation in obesity-prone rats is mediated by NAc CP-AMPARs. These neurobehavioral differences may render obesity-susceptible populations more sensitive to the motivational influence of food cues, producing more intense, focused, “wanting” that may limit t

• Cy5 NHS ester(Et) mg br Concluding remarks The past

  2023-09-19

  

  Concluding remarks The past decade has seen rapid advances in our understanding of the metabolic reprogramming that occurs during tumorigenesis. Strategies to target specific nodes of cancer cell amino Cy5 NHS ester(Et) mg metabolism have progressed from preclinical studies to clinical trials, a

• this page Modulating the ability of tumor cells to detoxify

  2023-09-19

  

  Modulating the ability of tumor this page to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tumor cell su

• In conclusion we have shown that

  2023-09-19

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, mpges-1 inhibitors tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of noradrener

• Interestingly our transgenic mouse model with macrophages

  2023-09-19

  

  Interestingly, our transgenic mouse model with macrophages expressing AdipoR1 showed not only improved insulin sensitivity and inflammation in skeletal muscle and adipose tissues, but fat mass, macrophage and plasma lipid accumulation and foam cell formation was also favorably reduced resulting from

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